New data on chronic hemodialysis patients show improved response to BNT162b2 anti-SARS-CoV-2 vaccine when treated with polymethylmethacrylate dialysis membrane compared to polysulfone.
Critically ill COVID-19 patients present a dysregulated host response to infection caused by the primary viral SARS-CoV-2 infection and/or subsequent bacterial superinfections. This can lead to conditions of unresponsive septic shock with high fatality rate.
Here we review the recent literature on COVID-19 pathophysiology and the application of Polymyxin B hemoperfusion (PMX-HP) for the management of critically ill COVID-19 patients with endotoxic shock