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COVID-19, Guidelines

Endotoxemia in critically ill COVID-19 patients – from pathophysiology to advanced targeted complementary therapies

Critically ill COVID-19 patients present a dysregulated host response to infection caused by the primary viral SARS-CoV-2 infection and/or subsequent bacterial superinfections. This can lead to conditions of unresponsive septic shock with high fatality rate.
Here we review the recent literature on COVID-19 pathophysiology and the application of Polymyxin B hemoperfusion (PMX-HP) for the management of critically ill COVID-19 patients with endotoxic shock

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Guidelines

WORLD SEPSIS DAY 2017

World Sepsis Day on September 13 aims to raise awareness of sepsis, an underestimated global healthcare problem affecting 31,500,000 people and causing 5,300,000 deaths annually.

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Guidelines

SURVIVING SEPSIS CAMPAIGN GUIDELINES 2016

The SSC guidelines are built on evidence-based medicine and are the most comprehensive guidelines available for the management of sepsis and septic shock.
Polymyxin B hemoperfusion therapy is included for the first time in the SSC guidelines, reflecting that evidence is accumulating for this therapy.